Animal models for host-pathogen interaction studies

Animal models for host-pathogen interactions.

www.sciencedirect.com Microbial infections are characterized by a continual dramatic interplay between pathogen and host: pathogens exploit an array of host cell functions during infection and their hosts respond with appropriate immune responses. Host–pathogen interactions are complex and dynamic by nature and are generally analyzed with a reductionist approach focusing on one facet of the int...

Host Pathogen Relations: Exploring Animal Models for Fungal Pathogens

Pathogenic fungi cause superficial infections but pose a significant public health risk when infections spread to deeper tissues, such as the lung. Within the last three decades, fungi have been identified as the leading cause of nosocomial infections making them the focus of research. This review outlines the model systems such as the mouse, zebrafish larvae, flies, and nematodes, as well as e...

Unconventional animal models: a booster for new advances in host—pathogen interactions

ANIMALS AS TOOLS Historically, biology has greatly benefited and is still benefiting from the study of animals. A quick search of the PubMed database for “animal models” yields some 41,000 studies, and many others will come. Once regarded as the subject of biological studies [Darwin’s finches are a wellknown example (Peterson, 2008)], animals have become tools to seize and solve the genetic sec...

Chromatin Remodelling During Host-Bacterial Pathogen Interaction

Host–Pathogen Interaction in Invasive Salmonellosis

Salmonella enterica infections result in diverse clinical manifestations. Typhoid fever, caused by S. enterica serovar Typhi (S. Typhi) and S. Paratyphi A, is a bacteremic illness but whose clinical features differ from other Gram-negative bacteremias. Non-typhoidal Salmonella (NTS) serovars cause self-limiting diarrhea with occasional secondary bacteremia. Primary NTS bacteremia can occur in t...